Mielina en la Salud y la Enfermedad

Nuestros estudios se enfocan en identificar mecanismos mediados por las células gliales que llevan a la neurodegeneración presente en la etapa progresiva de la Esclerosis Múltiple en modelo in vivo e in vitro de desmielinización.

Integrantes

Laura Pasquini

Publicaciones Destacadas

Thomas L., Pasquini L.A. Galectin-3-mediated glial crosstalk drives oligodendrocyte differentiation and (re)myelination. Front Cell Neurosci. 2018 Sep 12;12:297. doi: 10.3389/fncel.2018.00297. eCollection 2018.

Wies Mancini V.S.B., Pasquini J.M., Correale J.D., Pasquini L.A. Microglial modulation through CSF-1R inhibition attenuates demyelination and promotes remyelination. Glia. Wiley, EEUU. 2019 Feb;67(2):291-308. doi: 10.1002/glia.23540..

Wies Mancini VSB, Di Pietro AA, de Olmos S, Silva Pinto P, Vence M, Marder M, Igaz LM, Marcora MS, Pasquini JM, Correale JD, Pasquini LA. Colony-stimulating factor-1 receptor inhibition attenuates microgliosis and myelin loss but exacerbates neurodegeneration in the chronic cuprizone model. J Neurochem. 2021 Dec 22. doi: 10.1111/jnc.15566.

Di Pietro AA, Pasquini LA. A novel in vitro model for investigating oligodendroglial maturation and myelin deposition under demyelinating and remyelinating conditions: Impact of microglial depletion and repopulation. Mol Cell Neurosci. 2024 May 24;129:103937. doi: 10.1016/j.mcn.2024.103937

Thomas, L., Pasquini, M. V. G., & Pasquini, L. A. (2025). Quaking Protein in Myelin Maintenance and Regeneration in the Central Nervous System. Molecular neurobiology, 62(12), 15267–15283. https://doi.org/10.1007/s12035-025-05144-5

Colaboraciones

Belmonte, M., Cardoso, S. L., Di Pietro, A. A., Veigas, F., Pasquini, L. A., & Gelman, D. M. (2025). Intrinsic metabolic and immune impairments in a genetic mouse model of schizophrenia. Schizophrenia (Heidelberg, Germany), 11(1), 100. https://doi.org/10.1038/s41537-025-00651-9

Calanni, J. S., Pasquini, L. A., Dieguez, H. H., Aguirre, N. B., Berardino, B. G., Dorfman, D., & Rosenstein, R. E. (2025). Microglial depletion prevents visual deficits and retinal ganglion cell loss induced by early life stress in adult animals. Scientific reports, 15(1), 17143. https://doi.org/10.1038/s41598-025-01526-w