Parte de la producción científica del Instituto se refleja en la publicación de artículos científicos en revistas especializadas. A continuación enumeramos las publicaciones destacadas por cada laboratorio.
Enlace al sitio del laboratorio
Florencia Scochera, Gerardo Zerbetto De Palma, Agustina Canessa Fortuna, Jonathan Chevriau, Roxana Toriano, Gabriela Soto, Ari Zeida, Karina Alleva. PIP aquaporin pH sensing is regulated by the length and charge of the C-terminal region. The FEBS Journal (2022) 289, 246–26110.1111/febs.16134.
Fiorella C. Tesán, Ramiro Lorenzo, Karina Alleva, Romina Fox. AQPX-cluster aquaporins and aquaglyceroporins are asymmetrically distributed in trypanosomes. Commununications Biology (2021) 4, 953. doi:10.1038/s42003-021-02472-9.
Ana Romina Fox, Florencia Scochera, Timothée Laloux, Karilina Filik, Hervé Degand, Pierre Morsomme, Karina Alleva, François Chaumont. Plasma membrane aquaporins interact with the endoplasmic reticulum resident VAP27 proteins at ER-PM contact sites and endocytic structures. New Phytologist (2020) 228 (3), pp. 973-988. doi:10.1111/nph.16743.
Agustina Canessa Fortuna, Gerardo Zerbetto De Palma, Lucio Aliperti Car, Luciano Armentia, Victoria Vitali, Ari Zeida, Dario Estrin, Karina Alleva. Gating in plant plasma membrane aquaporins: the involvement of leucine in the formation of a pore constriction in the closed state. The FEBS Journal (2019) 286: 3473–3487. doi:10.1111/febs.14922
Victoria Vitali, Cintia Jozefkowicz, Agustina Canessa Fortuna, Gabriela Soto, F. Luis González-Flecha, Karina Alleva. Cooperativity in proton sensing by PIP aquaporins. The FEBS Journal (2019) 286(5):991-1002. doi.org/10.1111/febs.14701.
Cintia Jozefkowicz, Lorena Sigaut, Florencia Scochera, Gabriela Soto, Nicolás Ayub, Lía Pietrasanta, Gabriela Amodeo, F. Luis González-Flecha, Karina Alleva. PIP Water Transport and Its pH Dependence Are Regulated by Tetramer Stoichiometry, Biophysical Journal (2016) 110 (6) 1312-21. doi: 10.1016/j.bpj.2016.01.026.
Agustín Yaneff, Lorena Sigaut, Mercedes Marquez, Karina Alleva, Lía Isabel Pietrasanta, Gabriela Amodeo. Heteromerization of PIP aquaporins affects their intrinsic permeability. Proc Natl Acad Sci U S A (2014) 7;111(1):231-6. doi.org/10.1073/pnas.1316537111.
Cintia Jozefkowicz, Pablo Rosi, Lorena Signaut, Lia Pietrasanta, Gabriela Amodeo, Karina Alleva. Loop A Is Critical for the Functional Interaction of Two Beta vulgaris PIP Aquaporins. PLoS ONE (2013) 8(3): e57993. doi:10.1371/journal.pone.0057993.
Karina Alleva, Osvaldo Chara, Gabriela Amodeo. Aquaporins: Another piece in the osmotic puzzle. FEBS Letters (2012) 21;586(19):2991-9. doi.org/10.1016/j.febslet.2012.06.013.
Hanzel C.E., Almeira Gubiani M.F. y Verstraeten S.V. “Endosomes and lysosomes are involved in early steps of Tl(III)-mediated apoptosis in rat pheochromocytoma (PC12) cells”. Archives of Toxicology 86: 1667–1680 (2012). DOI: 10.1007/s00204-012-0878-3.
Puga Molina L.C., Salvatierra Fréchou D.M. y Verstraeten S.V. “Early response of glutathione- and thioredoxin-dependent antioxidant defense systems to Tl(I)- and Tl(III)-mediated oxidative stress in adherent pheochromocytoma (PC12adh) cells.” Archives of Toxicology 92: 195–211 (2018). DOI 10.1007/s00204-017-2056-0.
Pino M.T.L., Marotte C. y Verstraeten S.V. “Epidermal growth factor prevents thallium(I)- and thallium(III)-mediated rat pheochromocytoma (PC12) cell apoptosis.” Archives of Toxicology 91: 1157–1174 (2017). DOI 10.1007/s00204-016-1793-9.
Pino M.T.L. y Verstraeten S.V. “Tl(I) and Tl(III) alter the expression of EGF-dependent signals and cyclins required for pheochromocytoma (PC12) cell-cycle resumption and progression.” Journal of Applied Toxicology 35: 952–969 (2015). DOI 10.1002/jat.3096
Benavides M.P., Groppa M.D., Recalde L. y Verstraeten S.V. “Effects of polyamines on cadmium- and copper-mediated alterations in wheat (Triticum aestivum L) and sunflower (Helianthus annuus L) seedling membrane fluidity.” Archives of Biochemistry and Biophysics 654: 27–39 (2018). DOI: 10.1016/j.abb.2018.07.008.
Ferreira-Gomes M.S., Mangialavori I.C., Ontiveros M.Q., Rinaldi D.E., Martiarena J. *Verstraeten S.V. y *Rossi J.P.F.C. “Selectivity of plasma membrane calcium ATPase (PMCA)-mediated extrusion of toxic divalent cations in vitro and in cultured cells.” Archives of Toxicology 92: 273–288 (2018). DOI 10.1007/s00204-017-2031-9. *Ambos son autores correspondientes.
Verstraeten S.V., Jaggers G.K., Fraga C.G. y Oteiza P.I. “Procyanidins can interact with Caco-2 cell membrane lipid rafts: involvement of cholesterol.” Biochimica et Biophysica Acta-Biomembranes 1828: 2646–2653 (2013). DOI: 10.1016/j.bbamem.2013.07.023
Céliz G., Alfaro F., Cappellini C., Daz M. y Verstraeten S.V. “Prunin- and hesperetin glucoside-alkyl (C4-C18) esters interaction with cells plasma membrane: consequences on membrane physical properties and antioxidant capacity”. Food and Chemical Toxicology 55: 411–423 (2013). DOI: 10.1016/j.fct.2013.01.011
Fraga C.G., Galleano M., Verstraeten S.V., y Oteiza, P.I. “Basic biochemical mechanisms behind the health benefits of polyphenols.” Molecular Aspects of Medicine 31: 435–445 (2010). DOI: 10.1016/j.mam.2010.09.006.
Buffone M.G., Calamera J.C., Doncel G.F., y Verstraeten S.V. “Capacitation-associated changes in membrane fluidity in asthenozoospermic human spermatozoa.” International Journal of Andrology 32: 360–375 (2009). DOI: 10.1111/j.1365-2605.2008.00874.
Enlace al sitio del laboratorio
1: Corradi GR, Mazzitelli LR, Petrovich GD, de Tezanos Pinto F, Rochi L, Adamo HP. Plasma Membrane Ca<sup>2+</sup> Pump PMCA4z Is More Active Than Splicing Variant PMCA4x. Front Cell Neurosci. 2021 Aug 26;15:668371. doi: 10.3389/fncel.2021.668371. PMID: 34512262; PMCID: PMC8428515.
2: Corradi GR, Mazzitelli LR, Petrovich GD, Grenon P, Sørensen DM, Palmgren M, de Tezanos Pinto F, Adamo HP. Reduction of the P5A-ATPase Spf1p phosphoenzyme by a Ca2+-dependent phosphatase. PLoS One. 2020 Apr 30;15(4):e0232476. doi: 10.1371/journal.pone.0232476. PMID: 32353073; PMCID: PMC7192388.
3: Marcos AL, Corradi GR, Mazzitelli LR, Casali CI, Fernández Tome MDC, Adamo HP, de Tezanos Pinto F. The Parkinson-associated human P5B-ATPase ATP13A2 modifies lipid homeostasis. Biochim Biophys Acta Biomembr. 2019 Oct 1;1861(10):182993. doi: 10.1016/j.bbamem.2019.05.015. Epub 2019 May 24. PMID: 31132336.
4: de Tezanos Pinto F, Adamo HP. The strategic function of the P5-ATPase ATP13A2 in toxic waste disposal. Neurochem Int. 2018 Jan;112:108-113. doi: 10.1016/j.neuint.2017.11.008. Epub 2017 Nov 21. PMID: 29169913.
5: Mazzitelli LR, Adamo HP. Hyperactivation of the human plasma membrane Ca2+ pump PMCA h4xb by mutation of Glu99 to Lys. J Biol Chem. 2014 Apr 11;289(15):10761-10768. doi: 10.1074/jbc.M113.535583. Epub 2014 Feb 28. PMID: 24584935; PMCID: PMC4036192.
6: De La Hera DP, Corradi GR, Adamo HP, De Tezanos Pinto F. Parkinson’s disease-associated human P5B-ATPase ATP13A2 increases spermidine uptake. Biochem J. 2013 Feb 15;450(1):47-53. doi: 10.1042/BJ20120739. PMID: 23205587.
7: Corradi GR, de Tezanos Pinto F, Mazzitelli LR, Adamo HP. Shadows of an absent partner: ATP hydrolysis and phosphoenzyme turnover of the Spf1 (sensitivity to Pichia farinosa killer toxin) P5-ATPase. J Biol Chem. 2012 Aug 31;287(36):30477-84. doi: 10.1074/jbc.M112.363465. Epub 2012 Jun 28. PMID: 22745129; PMCID: PMC3436297.
8: Corradi GR, Adamo HP. Intramolecular fluorescence resonance energy transfer between fused autofluorescent proteins reveals rearrangements of the N- and C-terminal segments of the plasma membrane Ca2+ pump involved in the activation. J Biol Chem. 2007 Dec 7;282(49):35440-8. doi: 10.1074/jbc.M703377200. Epub 2007 Sep 27. PMID: 17901055.
9: Bredeston LM, Adamo HP. Loss of autoinhibition of the plasma membrane Ca(2+) pump by substitution of aspartic 170 by asparagin. Activation of plasma membrane calcium ATPase 4 without disruption of the interaction between the catalytic core and the C-terminal regulatory domain. J Biol Chem. 2004 Oct 1;279(40):41619-25. doi: 10.1074/jbc.M403116200. Epub 2004 Jul 29. PMID: 15292209.
10: Adamo HP, Filoteo AG, Enyedi A, Penniston JT. Mutants in the putative nucleotide-binding region of the plasma membrane Ca(2+)-pump. A reduction in activity due to slow dephosphorylation. J Biol Chem. 1995 Dec 15;270(50):30111-4. doi: 10.1074/jbc.270.50.30111. PMID: 8530416.
Romero DJ, Pescio LG, Santacreu BJ, Mosca JM, Sterin-Speziale N, Favale NO. “Sphingosine-1-phosphate receptor 2 plays a dual role depending on the stage of cell differentiation in renal epithelial cells” Life Sciences 316 (2023) 121404 (doi.org/10.1016/j.lfs.2023.121404).
Santacreu BJ, Pescio LG, Romero DJ, Corradi GR, Sterin-Speziale N, Favale NO. “Sphingosine kinase and sphingosine-1-phosphate regulate epithelial cell architecture by the modulation of de novo sphingolipid synthesis”. PLoS One. 14(3):e0213917 (2019) (doi: 10.1371/journal.pone.0213917).
Santacreu BJ, Romero DJ, Pescio LG, Tarallo E, Sterin-Speziale NB, Favale NO. “Apoptotic cell extrusion depends on single-cell synthesis of sphingosine-1-phosphate by sphingosine kinase 2”. Biochim Biophys Acta Mol Cell Biol Lipids 1866(4) (2021) 158888. (doi: 10.1016/j.bbalip.2021.158888).
Pescio LG, Santacreu BJ, Lopez VG, Paván CH, Romero DJ, Favale NO, Sterin-Speziale NB. “Changes in ceramide metabolism are essential in Madin-Darby Canine Kidney cell differentiation” J Lipid Res. 58(7) (2017) 1428-1438. (doi: 10.1194/jlr.M076349).Print ISSN 0022-2275; Online ISSN 1539-7262. ASBMB. Bethesda. USA.
NO Favale, BJ Santacreu, LG Pescio, MG Marquez and NB Sterin-Speziale. Sphingomyelin metabolism is involved in the differentiation of MDCK cells induced by environmental hypertonicity. J. Lipid Res 56 (2015) 786-800. (doi:10.1194/jlr.M050781). Print ISSN 0022-2275; Online ISSN 1539-7262. ASBMB. Bethesda. USA.
LG Pescio, NO Favale, MG Marquez, and NB Sterin-Speziale Glycosphingolipid synthesis is essential for MDCK cell differentiation. Biochim Biophys Acta- Molecular and Cell Biology of Lipids 1821(6) (2012) 884- 94. (doi: 10.1016/j.bbalip.2012.02.009) ISSN: 1388-1981. Elsevier. Amsterdam. The Netherlands.
LB Pena, LA Pasquini, ML Tomaro, SM Gallego (2007) 20S proteasome and accumulation of oxidized and ubiquitinated proteins in maize leaves subjected to cadmium stress. Phytochemistry 68(8):1139-1146. ISSN 0031-9422. doi: 10.1016/j.phytochem.2007.02.022
LB Pena, CL Matayoshi, AAE Méndez, M Arán, CJ Moratto, JM Vázquez-Ramos, SM Gallego (2020) Metabolic rearrangements in imbibed maize (Zea mays L.) embryos in the presence of oxidative stressors. Plant Physiology and Biochemistry 155:560-569. ISSN 0981-9428. doi: 10.1016/j.plaphy.2020.08.029
AAE Méndez, LB Pena, LM Curto, MM Fernández, EL Malchiodi, SM Garza-Aguilar, JM Vázquez-Ramos, SM Gallego (2020) Oxidation of proline from the cyclin-binding motif in maize CDKA;1 results in lower affinity with its cyclin regulatory subunit. Phytochemistry 112165. ISSN 0031-9422. doi: 10.1016/j.phytochem.2019.112165.
CL Matayoshi, LB Pena, V Arbona, A Gómez-Cadenas, SM Gallego (2022) Biochemical and hormonal changes associated with root growth restriction under cadmium stress during maize (Zea mays L.) pre-emergence. Plant Growth Regulation 96(12):269-281. ISSN 0167-6903. doi: 10.1007/s10725-021-00774-w.
CL Matayoshi, LB Pena, V Arbona, A Gómez-Cadenas, SM Gallego (2020) Early responses of maize seedlings to Cu stress include sharp decreases in gibberellins and jasmonates in the root apex. Protoplasma 257(4):1243-1256. ISSN 1615-6102. doi: 10.1007/s00709-020-01504-1.
LB Pena, AAE Méndez, CL Matayoshi, MS Zawoznik, SM Gallego (2015) Early response of wheat seminal roots growing under copper excess. Plant Physiology and Biochemistry 87:115-123. ISSN 0981-9428. doi: 10.1016/j.plaphy.2014.12.021
LB Pena, RA Barcia, CE Azpilicueta, AAE Méndez, SM Gallego (2012) Oxidative post translational modifications of proteins related to cell cycle are involved in cadmium toxicity in wheat seedlings. Plant Science 196(4):1-7. ISSN 0168-9452. doi: 10.1016/j.plantsci.2012.07.008
Enlace al sitio del laboratorio
Silva MG, Falcoff NL, Corradi GR, Alfie J, Seguel RF, Tabaj GC, Iglesias LI, Nuñez M, Guman GR, Gironacci MM. Renin-angiotensin system blockade on angiotensin-converting enzyme 2 and TMPRSS2 in human type II pneumocytes. Life Sci. 2022; 293:120324. doi: 10.1016/j.lfs.2022.120324
Silva MG, Corradi GR, Pérez Duhalde JI, Nuñez M, Cela EM, Gonzales Maglio DH, Brizzio A, Salazar MR, Espeche WG, Gironacci MM. Plasmatic renin-angiotensin system in normotensive and hypertensive patients hospitalized with COVID-19. Biomed Pharmacother. 2022;152:113201. doi: 10.1016/j.biopha.2022.113201
Silva MG, Falcoff NL, Corradi GR, di Camillo N, Seguel RF, Tabaj GC, Guman GR, de Mateo E, Nuñez M, Gironacci MM. Effect of Age on Human ACE2 and ACE2-Expressing Alveolar Type II Cells Levels. Pediatric Research 2022; 23:1-5. doi: 10.1038/s41390-022-02163-z.
Rukavina Mikusic NL, Silva MG, Mazzitelli LR, Santos RAS, Gómez KA, Grecco HE, Gironacci MM. Interaction Between the Angiotensin-(1-7) Mas Receptor and the Dopamine D2 Receptor: Implications in Inflammation. Hypertension. 2021; 77(5):1659-1669. doi: 10.1161/HYPERTENSIONAHA.120.16614
Rukavina Mikusic NL, Silva MG, Pineda AM, Gironacci MM. Angiotensin Receptors Heterodimerization and Trafficking: How Much Do They Influence Their Biological Function? Front Pharmacol. 2020;11:1179. doi: 10.3389/fphar.2020.01179
Cerniello FM, Silva MG, Carretero OA, Gironacci MM. Mas receptor is translocated to the nucleus upon agonist stimulation in brainstem neurons from spontaneously hypertensive rats but not normotensive rats. Cardiovasc Res 2020 116(12):1995-2008. doi: 10.1093/cvr/cvz332
Cerniello FM, Carretero OA, Longo Carbajosa NA, Cerrato BD, Santos RA, Grecco HE, Gironacci MM. MAS1 Receptor Trafficking Involves ERK1/2 Activation Through a β- Arrestin2-Dependent Pathway. Hypertension. 2017; 70:982-989. doi: 10.1161/HYPERTENSIONAHA.117.09789
Cerrato BD, Carretero OA, Janic B, Grecco HE, Gironacci MM. Heteromerization Between the Bradykinin B2 Receptor and the Angiotensin-(1-7) Mas Receptor: Functional Consequences. Hypertension 2016; 68:1039-48. doi: 10.1161/HYPERTENSIONAHA.116.07874.
Gironacci MM, Adamo HP, Corradi G, Santos RAS, Ortiz P, Carretero OA. Angiotensin-(1-induces Mas receptor internalization. Hypertension 2011; 58:176-81. doi: 10.1161/HYPERTENSIONAHA.111.173344
Goldstein J, Carden T, Perez MJ, Taira CA, Hocht C, Gironacci MM. Angiotensin-(1-7) Protects from Brain Damage Induced by Shiga Toxin 2-Producing Enterohemorrhagic Escherichia Coli. Am J Physiol Regul Integr Comp Physiol. 2016; 311:R1173-R1185. doi: 10.1152/ajpregu.00467.2015
“Adipose-derived Mesenchymal Stem Cell Magnetic Targeting for Injured Sciatic Nerve Regeneration”. Paula A. Soto, Marianela Vence, Gonzalo M. Piñero, Diego F. Coral, Vanina Usach, Diego Muraca, Alicia Cueto, Anna Roig, Marcela B. Fernández van Raap, Clara P. Setton-Avruj. Acta Biomater. 130: 234–247, 2021. doi: 10.1016/j.actbio.2021.05.050
Este manuscrito fue destacado por la revista Science en la seccion In other journals, Science vol. 372, issue 6548 pp 1301-1302, 18/6/2021.
“Systemic administration of bone marrow-derived cells promotes axonal regeneration and analgesia in a model of Wallerian degeneration”. Vanina Usach, Mariana Malet, Margarita López, Lucía Lavalle, Gonzalo Piñero, María Saccoliti, Alicia Cueto, Pablo Brumovsky, Alicia Brusco and Patricia Setton-Avruj. Transplantation, 101(7):1573-1586, 2017. doi: 10.1097/TP.0000000000001478
“EGFP transgene: a useful tool to track transplanted bone marrow mononuclear cell contribution to peripheral remyelination”. Gonzalo Piñero, VaninaUsach, Paula A. Soto, Paula V. Monje and Patricia C. Setton-Avruj. Transgenic Res. Apr;27(2):135-153, 2018. doi: 10.1007/s11248-018-0062-5
“Bone marrow mononuclear cells migrate to the demyelinated sciatic nerve and transdifferentiate into Schwann cells: an attempt at an endogenous repair mechanism after nerve injury”. Vanina Usach, Belén Goitia, Lucía Lavalle, Rocío Martinez Vivot and Patricia Setton-Avruj. Journal of Neuroscience Research 89:1203–1217, 2011. doi: 10.1002/jnr.22645
«All the PNS is a stage: transplanted bone marrow cells play an immunomodulatory role in peripheral nerve regeneration». Gonzalo Piñero, Marianela Vence, Marcos L. Aranda, Magalí C. Cercato, Paula A. Soto, Vanina Usach and Patricia Setton-Avruj. En prensa en ASN Neuro abril 2023.
“DMT1 as a candidate for non-transferrin-bound iron uptake in the peripheral nervous system”. Rocio Martinez Vivot, Belén Goitia, Vanina Usach and Patricia Setton-Avruj. Biofactors. 39 (4): 476-484, 2013. doi: 10.1002/biof.1088
“DMT1 iron uptake in the PNS: bridging the gap between injury and regeneration” Rocio Martinez Vivot, Guillermo Copello, Celeste Leal, Gonzalo Piñero, Laura Morelli, Clara Patricia Setton-Avruj. Metallomics, 2015, 7, 1381-1389. doi: 10.1039/c5mt00156k
Endocrine disruptor chlorpyrifos promotes migration, invasion, and stemness phenotype in 3D cultures of breast cancer cells and induces a wide range of pathways involved in cancer progression. Marianela Soledad Lasagna; Clara Ventura; Maria Soledad Hielpos; Mariana Noelia Mardirosian; Gabriela Martín; Noelia Miret; Andrea Randi; Mariel Nuñez; Claudia Marcela Cocca. Environmental Res 204 (2022) 111989. doi: 10.1016/j.envres.2021.111989.
Chronic exposure to low concentrations of chlorpyrifos affects normal cyclicity and histology of the uterus in female rats. María Rosa Ramos Nieto; Marianela Lasagna; Gabriel Cao; Gloria Álvarez; Clarisa Santamaria; María Eugenia Rodriguez Girault; Nadia Bourguignon, Noelia Di Giorgio; Clara Ventura; Mariana Mardirosian; Horacio Rodriguez; Victoria Lux-Llantos; Claudia Cocca; Mariel Núñez. Food and Chemical Toxicology 2021 Oct;156:112515. doi: 10.1016/j.fct.2021.112515.
Chlorpyrifos subthreshold exposure induces epithelial-mesenchymal transition in breast cancer cells. Marianela Lasagna; Soledad Hielpos; Clara Ventura; Mariana Mardirosian; Gabriela Martin; Noelia Miret; Andrea Randi; Mariel Núñez; Claudia Cocca. Ecotoxicol Environ Saf. 2020 Dec 1;205:111312. doi: 10.1016/j.ecoenv.2020.111312.
Differential expression of the long and truncated Hv1 isoforms in breast-cancer cells. Ventura, C.; Leon, I.E.; Asuaje, A.; Martín, P.; Enrique, N.; Núñez, M.; Cocca, C.; Milesi, V. J Cell Physiol. (2020) 235(11):8757-8767. doi: 10.1002/jcp.29719. Epub 2020 Apr 23.
Impact of endocrine disruptor hexachlorobenzene on the mammary gland and breast cancer: The story thus far. Review. Miret NV, Pontillo CA, Zárate LV, Kleiman de Pisarev D, Cocca C, Randi AS. Environ Res. 173: 330-34 (2019); doi: 10.1016/j.envres.2019.03.054; Review.
Effects of the pesticide chlorpyrifos on breast cancer disease. Implication of epigenetic mechanisms. Ventura Clara, Zappia Carlos Daniel, Pavicic Walter, Richard Silvina, Bolzan Alejandro D, Monczor Federico, Núñez Mariel, Cocca Claudia. Steroid and Biochem Molec Biol. 186: 96-104 (2019); doi: 10.1016/j.jsbmb.2018.09.021.
Enlace al sitio del laboratorio
Adler NS, Cababie LA, Sarto C, Cavasotto CN, Gebhard LG, Estrin DA, Gamarnik AV, Arrar M, Kaufman SB. Insights into the product release mechanism of dengue virus NS3 helicase. Nucleic Acids Res. 2022 Jul 8;50(12):6968-6979. doi: 10.1093/nar/gkac473. PMID: 35736223; PMCID: PMC9262617.
Sarto C, Kaufman SB, Estrin DA, Arrar M. Nucleotide-dependent dynamics of the Dengue NS3 helicase. Biochim Biophys Acta Proteins Proteom. 2020 Aug;1868(8):140441. doi: 10.1016/j.bbapap.2020.140441. Epub 2020 May 1. PMID: 32371149.
Cababie LA, Incicco JJ, González-Lebrero RM, Roman EA, Gebhard LG, Gamarnik AV, Kaufman SB. Thermodynamic study of the effect of ions on the interaction between dengue virus NS3 helicase and single stranded RNA. Sci Rep. 2019 Jul 22;9(1):10569. doi: 10.1038/s41598-019-46741-4. PMID: 31332207; PMCID: PMC6646317
Gebhard, L. G., Incicco, J. J., Smal, C., Gallo, M., Gamarnik, A. V., & Kaufman, S. B. (2015). Monomeric nature of dengue virus NS3 helicase and thermodynamic analysis of the interaction with single-stranded RNA. Nucleic Acids Research, 42(18), 11668-11686. PubMed
Cattoni DI, Chara O, Kaufman SB, González Flecha FL (2015) Cooperativity in Binding Processes: New Insights from Phenomenological Modeling. PLoS ONE 10(12): e0146043. https://doi.org/10.1371/journal.pone.0146043
Incicco, J. J., Gebhard, L. G., González-Lebrero, R. M., Gamarnik, A. V., & Kaufman, S. B. (2013). Steady-state NTPase activity of Dengue virus NS3: Number of catalytic sites, nucleotide specificity and activation by ssRNA. PloS One, 8(3), e58508. PubMed
Gebhard, L. G., Kaufman, S. B., & Gamarnik, A. V. (2012). Novel ATP-independent RNA annealing activity of the dengue virus NS3 helicase. PLoS One, 7(4), e36244. PubMed
Cattoni, D. I., Kaufman, S. B., & Flecha, F. (2009). Kinetics and thermodynamics of the interaction of 1-anilino-naphthalene-8-sulfonate with proteins. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 1794(11), 1700-1708. PubMed
M. Agueda Placenti, EA. Roman, F. Luis González Flecha and RM. González Lebrero. “Functional characterization of Legionella pneumophila Cu+ transport ATPase. The activation by Cu+ and ATP”. Biochim Biophys Acta -Biomembrane. 2022, 1864(2), 183822 https://doi.org/10.1016/j.bbamem.2021.183822.
Recoulat Angelini AA, Placenti MA, Melian NA, Sabeckis ML, Burgardt NI, González Lebrero RM, Roman EA, González Flecha FL. Cu(I)-Transport ATPases. Molecular architecture, catalysis and adaptation to extreme environments. Adv Med Biol. 2021 180, 65-130.
González-Lebrero RM*, Defelipe LA, Modenutti CP, Roitberg AE, Batastini NA, Noguera ME, Santos J, Roman EA*. Folding and Dynamics Are Strongly pH-Dependent in a Psychrophile Frataxin. J Phys Chem B. 2019, 123, 7676−7686. doi: 10.1021/acs.jpcb.9b05960.
Johanna G. Miquet*, Lorena González, Ana I. Sotelo, Rodolfo M. González Lebrero*. A laboratory work to introduce biochemistry undergraduate students to basic enzyme kinetics ‐alkaline phosphatase as a model. Biochemistry and Molecular Biology Education. 2019 47(1):93-99. doi: 10.1002/bmb.21195.
M. Agueda Placenti, Sergio B. Kaufman, F. Luis González Flecha and Rodolfo M. González Lebrero*. Unexpected Effects of K+ and Adenosine Triphosphate on the Thermal Stability of Na+,K+-ATPase. J. Phys. Chem. B. 121: 4949−4957 (2017). DOI: 10.1021/acs.jpcb.7b00629.
Faraj SE *, González-Lebrero RM *, Roman EA, Santos J. Human Frataxin Folds Via an Intermediate State. Role of the C-Terminal Region. Nature/Sci Rep. 2016 Feb 9;6:20782. doi: 10.1038/srep20782. (2016) *THESE AUTHORS CONTRIBUTED EQUALLY TO THIS WORK
Piazza VG, Cicconi NS, Martinez CS, Dominici FP, Miquet JG, Sotelo AI. 2023 Liver impact of growth hormone (GH) intermittent treatment during the growth period in mice. Mol Cell Endocrinol. 566–567, 111911. doi.org/10.1016/j.mce.2023.111911
González L, Díaz ME, Miquet JG, Sotelo AI, Dominici FP. 2021 Growth hormone modulation of hepatic epidermal growth factor receptor signaling. Trends in Endocrinolgy and Metabolism. 32(6):403-414 ISSN- 1043-2760. DOI: 10.1016/j.tem.2021.03.004
Piazza VG, Bartke A, Miquet JG, Sotelo AI. 2017 Analysis of Different Approaches for the Selection of Reference Genes in RT-qPCR Experiments: A Case Study in Skeletal Muscle of Growing Mice. Int J Mol Sci. 18(5):1060. pii: E1060. doi: 10.3390/ijms18051060. EISSN 1422-0067
Martinez CS, Piazza VG, González L, Fang Y, Bartke A, Turyn D, Miquet JG, Sotelo AI. Mitogenic signaling pathways in the liver of growth hormone (GH)-overexpressing mice during the growth period. 2016 Cell Cycle 15(5):748-59. ISSN: 1538-4101, doi: 10.1080/15384101.2016.1148844
Martinez CS, Piazza VG, Díaz ME, Boparai RK, Arum O, Ramírez MC, Gonzalez L, Becú-Villalobos D, Bartke A, Turyn D, Miquet JG, Sotelo AI. 2015 Growth hormone (GH)/STAT5 signaling during the growth period in liver of mice overexpressing GH. 9 doi: 10.1530/JME-14-0262. ISSN 0952-5041
Martinez Carolina S, Piazza Verónica G, Ratner Laura D, Matos Marina N, González Lorena, Rulli Susana B, Miquet Johanna G, Sotelo Ana I. 2013 Growth hormone STAT5-mediated signaling and its modulation in mice liver during the growth period. Growth Hormone and IGF Research. 1096-6374 23(1-2):19-28. DOI: 10.1016/j.ghir.2012.11.002
Miquet JG, Freund T, Martinez CS, González L, Diaz ME, Micucci GP, Zotta E, Boparai RK, Bartke A, Turyn D, Sotelo AI. 2013 Hepatocellular alterations and dysregulation of oncogenic pathways in the liver of transgenic mice overexpressing growth hormone. Cell Cycle 21;12(7): 1042-57. ISSN 1538-4101 DOI: 10.4161/cc.24026
González L, Díaz ME, Miquet JG, Sotelo AI, Dominici FP, Bartke A, Turyn D. 2010 Growth hormone (GH) modulates hepatic epidermal growth factor (EGF) signaling in the mouse. J Endocrinol, 0022-0795, 204(3):299-309. DOI: 10.1677/JOE-09-0372
Sotelo AI, Miquet JG, González L, Bartke A, Turyn D. Vitamin D cannot revert desensitization of growth hormona (GH)-induced STAT5-signaling in GH-overexpressing mice non-calcemic tissues. Growth hormone and IGF Research, ISSN 1096-6374 2008, 18 (2):148-156; doi: 10.1016/j.ghir.2007.08.001
González L, Curto LM, Miquet JG, Bartke A, Turyn D, Sotelo AI. Differential regulation of membrane associated-growth hormone binding protein (MA-GHBP) and growth hormone receptor (GHR) expression by growth hormone (GH) in mouse liver. Growth hormone and IGF Research, ISSN 1096-6374 2007 17(2):104-12. doi: 10.1016/j.ghir.2006.12.002
Muñoz MC, Piazza VG, Burghi V, Giani JF, Martinez CS, Cicconi NS, Muia NV, Fang Y, Lavandero S, Sotelo AI, Bartke A, Pennisi PA, Dominici FP, Miquet JG. Insulin signaling in the heart is impaired by growth hormone: a direct and early event. J Mol Endocrinol. 2022 Jun 23;69(2):357-376. doi: 10.1530/JME-21-0242.
Piazza VG, Matzkin ME, Cicconi NS, Muia NV, Valquinta S, Mccallum GJ, Micucci GP, Freund T, Zotta E, González L, Frungieri MB, Fang Y, Bartke A, Sotelo AI, Miquet JG. Exposure to growth hormone is associated with hepatic up-regulation of cPLA2α and COX. Mol Cell Endocrinol. 2020 Jun 1;509:110802. doi: 10.1016/j.mce.2020.110802.
Bacigalupo ML, Piazza VG, Cicconi NS, Carabias P, Bartke A, Fang Y, Sotelo AI, Rabinovich GA, Troncoso MF, Miquet JG. Growth hormone upregulates the pro-tumorigenic galectin 1 in mouse liver. Endocr Connect. 2019 Aug 1;8(8):1108-1117. doi: 10.1530/EC-19-0292.
Miquet JG, Freund T, Martinez CS, González L, Díaz ME, Micucci GP, Zotta E, Boparai RK, Bartke A, Turyn D, Sotelo AI. Hepatocellular alterations and dysregulation of oncogenic pathways in the liver of transgenic mice overexpressing growth hormone. Cell Cycle. 2013 Apr 1;12(7):1042-57. doi: 10.4161/cc.24026.
Miquet JG, Giani JF, Martinez CS, Muñoz MC, González L, Sotelo AI, Boparai RK, Masternak MM, Bartke A, Dominici FP, Turyn D. Prolonged exposure to GH impairs insulin signaling in the heart. J Mol Endocrinol. 2011 Aug 30;47(2):167-77. doi: 10.1530/JME-11-0066.
González L, Díaz ME, Miquet JG, Sotelo AI, Dominici FP. Growth Hormone Modulation of Hepatic Epidermal Growth Factor Receptor Signaling. Trends Endocrinol Metab. 2021 Jun;32(6):403-414. doi: 10.1016/j.tem.2021.03.004.
Bojorge MA, Cicconi NS, Cebrón JR, Fang Y, Lamb CA, Bartke A, Miquet JG, González L. Morphological and molecular effects of overexpressed GH on mice mammary gland. Mol Cell Endocrinol. 2021 Dec 1;538:111465. doi: 10.1016/j.mce.2021.111465.
Miquet JG, González L, Matos MN, Hansen CE, Louis A, Bartke A, Turyn D, Sotelo AI. Transgenic mice overexpressing GH exhibit hepatic upregulation of GH-signaling mediators involved in cell proliferation. J Endocrinol. 2008 Aug;198(2):317-30. doi: 10.1677/JOE-08-0002.
González L, Miquet JG, Irene PE, Díaz ME, Rossi SP, Sotelo AI, Frungieri MB, Hill CM, Bartke A, Turyn D. Attenuation of epidermal growth factor (EGF) signaling by growth hormone (GH). J Endocrinol. 2017 May;233(2):175-186. doi: 10.1530/JOE-16-0606.
Díaz ME, Miquet JG, Rossi SP, Irene PE, Sotelo AI, Frungieri MB, Turyn D, González L. GH administration patterns differently regulate epidermal growth factor signaling. J Endocrinol. 2014 Apr 22;221(2):309-23. doi: 10.1530/JOE-13-0447.
Dominici FP, D Cifone, A Bartke, Turyn D. Loss of sensitivity to insulin at early events of the insulin signaling pathway in the liver of growth hormone-transgenic mice. J Endocrinol 161:383-392, 1999. https://pubmed.ncbi.nlm.nih.gov/10333541/
Dominici FP, Hauck S, Argentino DP, Bartke A, Turyn D. Increased Insulin Sensitivity and Up-Regulation of Insulin Receptor, Insulin Receptor Substrate (IRS)-1 and IRS-2 in Liver of Ames dwarf mice. J Endocrinol 173:81-94, 2002. https://pubmed.ncbi.nlm.nih.gov/11927387/
Giani JF, Gironacci MM, Muñoz MC, Pena C, Turyn D, Dominici FP. Angiotensin-(1-7) stimulates the phosphorylation of JAK2, IRS-1 and Akt in rat heart in vivo: role of the AT1 and Mas receptors. Am J Physiol Heart Circ Physiol 293:H1154-H1163, 2007. https://pubmed.ncbi.nlm.nih.gov/17496209/
Bonkowski MS, Dominici FP, Arum O, Rocha JS, Al-Regaiey Khalid, Westbrook R, Spong A, Panici J, Masternak MM, Kopchick JJ, Bartke A. Disruption of Growth Hormone Receptor Prevents Calorie Restriction from Improving Insulin Action and Longevity. PLoS ONE 4(2):e4567, 2009. https://pubmed.ncbi.nlm.nih.gov/19234595/
Giani JF, Burghi V, Veiras LC, Tomat A, Muñoz MC, Cao G, Turyn D, Toblli JE, Dominici FP. Angiotensin-(1-7) Attenuates Diabetic Nephropathy in Zucker Diabetic Fatty Rats. Am J Physiol Renal Physiol 302: F1606-F1615, 2012. https://pubmed.ncbi.nlm.nih.gov/22492942/
Santos SH, Giani JF, Burghi V, Miquet JG, Qadri F, Braga JF, Todiras M, Kotnik K, Alenina N, Dominici FP, Santos RAS, Bader M. Oral Administration of Angiotensin-(1-7) Ameliorates Type 2 Diabetes in Rats. J Mol Med 92:255-265, 2014. https://pubmed.ncbi.nlm.nih.gov/24162089/
Dominici FP, Veiras LC, Shen JZY, Bernstein EA, Quiroga DT, Steckelings UM, Bernstein KE, Giani JF. Activation of AT2 receptors prevents diabetic complications in female db/db mice by NO-mediated mechanisms. Br J Pharmacol 177:4766-4781, 2020. https://pubmed.ncbi.nlm.nih.gov/32851652/
Muñoz MC, Piazza VG, Burghi V, Giani JF, Martinez CS, Cicconi NS, Muia NV, Fang Y, Lavandero S, Sotelo AI, Bartke A, Pennisi PA, Dominici FP, Miquet JG. Insulin signaling in the heart is directly and early impaired by growth hormone. J Mol Endocrinol 69: 357-376, 2022. https://pubmed.ncbi.nlm.nih.gov/35608964/
Conformational changes during the reaction cycle of the plasma membrane calcium pump in the autoinhibited and activated states. Saffioti NA, de Sautu M, Riesco AS, Ferreira-Gomes MS, Rossi JPFC, Mangialavori IC. Biochem J (2021) 478(10): 2019-2034 DOI: 10.1042/BCJ20210036
Epigallocatechin 3-gallate inhibits the plasma membrane Ca2+-ATPase: effects on calcium homeostasis. Rinaldi D, Ontiveros M, Saffioti NA, Vigil M, Mangialavori IC, Rossi RC, Rossi JP, Espelt MV and Ferreira-Gomes MS. Heliyon (2021) 7(2) DOI: 10.1016/j.heliyon.2021.e06337
Natural flavonoids inhibit the plasma membrane Ca2+-ATPase. Ontiveros M, Rinaldi D, Marder M, Espelt MV, Mangialavori I, Vigil M, Rossi JP, Ferreira-Gomes M. Biochem Pharmacol. (2019) 6;166:1-11 DOI: 10.1016/j.bcp.2019.05.004
E2P-like states of plasma membrane Ca2+‑ATPase characterization of vanadate and fluoride-stabilized phosphoenzyme analogues. Saffioti NA, de Sautu M, Ferreira-Gomes MS, Rossi RC, Berlin J, Rossi JPFC, Mangialavori IC. Biochim Biophys Acta Biomembr. (2019) 861(2):366-379. DOI: 10.1016/j.bbamem.2018.11.001
Aluminum Inhibits the Plasma Membrane and Sarcoplasmic Reticulum Ca2+-ATPases by Different Mechanisms. De Sautu M, Saffioti NA, Ferreira-Gomes MS, Rossi RC, Rossi JPFC and Mangialavori IC. BBA-Biomembrane (2018) 860(8):1580-1588. DOI: 10.1016/j.bbamem.2018.05.014
Cortical cytoskeleton dynamics regulates plasma membrane calcium ATPase isoform-2 (PMCA2) activity. Dalghi MG, Ferreira-Gomes M, Montalbetti N, Simonin A, Strehler EE, Hediger MA, Rossi JP. Biochim Biophys Acta Mol Cell Res. (2017) 1864(8):1413-1424. DOI: 10.1016/j.bbamcr.2017.05.014
Selectivity of plasma membrane calcium ATPase (PMCA)-mediated extrusion of toxic divalent cations in vitro and in cultures cells. Ferreira-Gomes MS1, Mangialaviri IC, Ontiveros MQ, Rinaldi, DE, Martiarena J, Verstraeten SV, Rossi JPFC. Arch. Toxicol. (2017) 92(1):273-288. DOI: 10.1007/s00204-017-2031-9
Modulation of Plasma Membrane Calcium Pump by Neutral Phospholipids: Effect of Micelle-Vesicle Transition and Bilayer Thickness. Pignataro MF, Dodes-Traian M, Gonzales-Flecha L, Sica M, Mangialavori IC and Rossi JPFC. J. Biol. Chem. (2015) 290: 6179-90 DOI: 10.1074/jbc.M114.585828
Plasma membrane calcium ATPase activity is regulated by actin oligomers through direct interaction. Dalghi MG, Fernández MM, Ferreira-Gomes M, Mangialavori IC, Malchiodi EL, Strehler EE and Rossi JP. J Biol Chem. (2013) 288(32):23380-93 DOI: 10.1074/jbc.M113.470542
Conformational changes produced by ATP binding to the plasma membrane calcium pump. Mangialavori IC, Ferreira-Gomes MS, Saffioti NA, González-Lebrero RM, Rossi RC, Rossi JP. J. Biol. Chem. (2013) 288(43):31030-41 DOI: 10.1074/jbc.M113.494633
- Novel roles of galectin-1 in hepatocellular carcinoma cell adhesion, polarization and in vivo tumor growth. Espelt MV, Croci DO, Bacigalupo ML, Carabias P, Manzi M, Elola MT, Muñoz MC, Dominici FP, Wolfenstein-Todel C, Rabinovich GA, Troncoso MF. Hepatology (2011) 53: 2097-106. Factor de Impacto 2011: 11.665.DOI: 10.1002/hep.24294 https://pubmed.ncbi.nlm.nih.gov/21391228/
- Galectin-1 confers resistance to doxorubicin in hepatocellular carcinoma cells through modulation of P-glycoprotein expression. Carabias P, Espelt MV, Bacigalupo ML, Rojas P, Sarrias L, Rubin A, Saffioti NA, Elola MT, Rossi JP, Wolfenstein-Todel C, Rabinovich GA, Troncoso MF. Cell Death Dis. (2022) 13(1):79. Factor de Impacto 2022: 9.696 DOI: 10.1038/s41419-022-04520-6 https://pubmed.ncbi.nlm.nih.gov/35075112/
- Modulation of endothelial cell migration and angiogenesis: a novel function for the “tandem-repeat” lectin galectin-8. Delgado VM, Nugnes LG, Colombo LL, Troncoso MF, Fernández MM, Malchiodi EL, Frahm I, Croci DO, Rabinovich GA, Wolfenstein-Todel C, Elola MT. FASEB Journal (2011) 25: 242-254. Factor de Impacto 2011: 5.711DOI: 10.1096/fj.09-144907 https://pubmed.ncbi.nlm.nih.gov/20876211/
- Glycosylation-dependent binding of galectin-8 to activated leukocyte cell adhesion molecule (ALCAM/CD166) promotes its surface segregation on breast cancer cells. Fernandez MM, Ferragut F, Cardenas Delgado VM, Bracalente C, Bravo AI, Cagnoni AJ, Nuñez M, Morosi LG, Quinta HR, Espelt MV, Troncoso MF, Wolfenstein-Todel C, Mariño KV, Malchiodi EL, Rabinovich GA, Elola MT. Biochimica et Biophysica Acta (BBA)-General Subjects (2016) 1860(10): 2255-2268. Factor de Impacto 2016: 4.702DOI: 10.1016/j.bbagen.2016.04.019 https://pubmed.ncbi.nlm.nih.gov/27130882/
- Galectin-1 triggers epithelial-mesenchymal transition in human hepatocellular carcinoma cells. Bacigalupo ML, Manzi M, Espelt MV, Compagno D, Laderach D, Wolfenstein-Todel C, Rabinovich GA, Troncoso MF. Journal of Cellular Physiology (2015) 230: 1298-1309. Factor de Impacto 2015: 4.155. DOI: 10.1002/jcp.24865 https://pubmed.ncbi.nlm.nih.gov/25469885/
- Dual knockdown of Galectin-8 and its glycosylated ligand, the activated leukocyte cell adhesion molecule (ALCAM/CD166), synergistically delays in vivo breast cancer growth. Ferragut F, Cagnoni AJ, Colombo LL, Sanchez Terrero C, Wolfenstein-Todel C, Troncoso MF, Vanzulli SI, Rabinovich GA, Mariño KV, Elola MT. Biochimica et Biophysica Acta (BBA)-Molecular Cell Res. (2019) 1866: 1338-1352. Factor de Impacto 2019: 4.105. DOI: 10.1016/j.bbamcr.2019.03.010 https://pubmed.ncbi.nlm.nih.gov/30905597/
- Galectin-1 controls the proliferation and migration of liver sinusoidal endothelial cells and their interaction with hepatocarcinoma cells. Manzi M, Bacigalupo ML, Carabias P, Elola MT, Wolfenstein-Todel C, Rabinovich GA, Espelt MV, Troncoso MF. Journal of Cellular Physiology (2016) 231: 1522-1533. Factor de Impacto 2016: 4.080.DOI: 10.1002/jcp.25244 https://pubmed.ncbi.nlm.nih.gov/26551914/
- ALCAM/CD166: a pleiotropic mediator of cell adhesion, stemness and cancer progression. Ferragut F, Vachetta VS, Troncoso MF, Rabinovich GA, Elola MT. Cytokine and Growth Factor Reviews (2021) 61:27-37. Factor de Impacto 2021: 7.638. DOI: 10.1016/j.cytogfr.2021.07.001 https://pubmed.ncbi.nlm.nih.gov/34272152/
- Extracellular ATP and adenosine in tumor microenvironment: roles in epithelial-mesenchymal transition, cell migration and invasion. Alvarez C, Troncoso MF, Espelt MV. Journal of Cellular Physiology (2022) 237:389-400. Factor de Impacto 2022: 6.513.DOI: 10.1002/jcp.30580 https://pubmed.ncbi.nlm.nih.gov/34514618/
- Opportunities, obstacles and current challenges of flavonoids for luminal and triple-negative breast cancer therapy. Vachetta VS, Marder M, Troncoso MF, Elola MT. European Journal of Medicinal Chemistry Reports (2022) 6:100077. https://doi.org/10.1016/j.ejmcr.2022.100077 https://www.sciencedirect.com/science/article/pii/S2772417422000498
“Inoculation with Azospirillum argentinense Az19 improves the yield of maize subjected to water deficit at key stages of plant development” JE Garcia, M Ruiz, GA Maroniche, C Creus, M Puente, MS Zawoznik, MD Groppa. Revista Argentina de Microbiologia, 2023, https://doi.org/10.1016/j.ram.2023.01.002.
“Azospirillum brasilense Az39 restricts cadmium entrance into wheat plants and mitigates cadmium stress” AVazquez, M Zawoznik, MP Benavides, MD Groppa. Plant Science, 2021, 312, 111056. 10.1016/j.plantsci.2021.111056
“In vitro PGPR properties and osmotic tolerance of different Azospirillum native strains and their effects on growth of maize under drought stress” JE Garcia, G Maroniche, C Creus, R Suarez-Rodriguez, JA Ramirez-Trujillo, MD Groppa. Microbiological Research (Q2), 2017, 202:21-29. https://doi.org/10.1016/j.micres.2017.04.007
“Wheat seeds harbour bacterial endophytes with potential as plant growth promoters and biocontrol agents of Fusarium graminearum” S. Diaz Herrera, C. Grossi, M. Zawoznik, M.D. Groppa. Microbiological Research (2.723 Q2), 2016, 186:37-43. https://doi.org/10.1016/j.micres.2016.03.002
“Response to saline stress and aquaporins expression in Azospirillum-inoculated barley seedlings” M.S. Zawoznik, M. Ameneiros, M.P. Benavides, S. Vazquez, M.D. Groppa. Applied Microbiology and Biotechnology (3.425, Q1), 2011, 90: 1389-1397. https://doi.org/10.1007/s00253-011-3162-1.
“Beneficial effects of magnetite nanoparticles on soybean-Bradyrhizobium japonicum and alfalfa-Sinorhizobium meliloti associations” MD Groppa, MS Zawoznik, MP Benavides, MF Iannone. Plant Physiology and Biochemistry, 2022, 180, 42-49. doi: 10.1016/j.plaphy.2022.03.025.
“Development and testing of a 3D-printable polylactic acid device to optimize a water bioremediation process” PL Marconi, A Trentini, M Zawoznik, C Nadra, JM Mercade, J Sanchez Novoa, D Orozco, MD Groppa. AMB Express, 2020, 10:142 https://doi.org/10.1186/s13568-020-01081-9
“Optimization of a Bioremediation Strategy for an Urban Stream of Matanza-Riachuelo Basin” MD Groppa, A Trentini, M Zawoznik, R Bigi, C Nadra, PL Marconi. International Journal of Environmental and Ecological Engineering, 2019, 13:418-424. http://dx.doi.org/10.5281/zenodo.3298858
Enlace a google scholar:
https://scholar.google.com/citations?user=pK0tl3UAAAAJ&hl=en
Pibuel M, Poodts D; Díaz M; Amoia S; Byrne A; Hajos S; Franco P; Lompardía S. (2023). 4-Methylumbelliferone enhances the effects of chemotherapy on both temozolomide-sensitive and resistant glioblastoma cells. Scientific Reports 2023, en prensa.
Molinari, Y. A., Byrne, A. J., Pérez, M. J., Silvestroff, L., & Franco, P. G. (2023). The Effects of Cuprizone on Murine Subventricular Zone-Derived Neural Stem Cells and Progenitor Cells Grown as Neurospheres. Molecular Neurobiology, 60(3), 1195–1213. https://doi.org/10.1007/s12035-022-03096-8 https://pubmed.ncbi.nlm.nih.gov/36424468/
Pibuel, M. A., Poodts, D., Molinari, Y., Díaz, M., Amoia, S., Byrne, A., Hajos, S., Lompardía, S., & Franco, P. (2023). The importance of RHAMM in the normal brain and gliomas: physiological and pathological roles. British journal of cancer, 128(1), 12–20. https://doi.org/10.1038/s41416-022-01999-w. https://pubmed.ncbi.nlm.nih.gov/36207608/
Pibuel, M. A., Poodts, D., Díaz, M., Molinari, Y. A., Franco, P. G., Hajos, S. E., & Lompardía, S. L. (2021). Antitumor effect of 4MU on glioblastoma cells is mediated by senescence induction and CD44, RHAMM and p-ERK modulation. Cell death discovery, 7(1), 280. https://doi.org/10.1038/s41420-021-00672-0 https://pubmed.ncbi.nlm.nih.gov/34628469/
Pibuel, M. A., Díaz, M., Molinari, Y., Poodts, D., Silvestroff, L., Lompardía, S. L., Franco, P., & Hajos, S. E. (2021). 4-Methylumbelliferone as a potent and selective antitumor drug on a glioblastoma model. Glycobiology, 31(1), 29–43. https://doi.org/10.1093/glycob/cwaa046 https://pubmed.ncbi.nlm.nih.gov/32472122/
Faraj, S.E., Valsecchi, W.M., Ferreira-Gomes, M., Centeno, M., Saint Martin, E.M., Fedosova, N.U., Rossi, J.P.F., Montes, M.R., Rossi, R.C.
Measurements of Na+-occluded intermediates during the catalytic cycle of the Na+/K+-ATPase provide novel insights into the mechanism of Na+ transport (2023) Journal of Biological Chemistry, 299 (2), art. no. 102811. DOI: 10.1016/j.jbc.2022.102811
Bardossy, E.S., Volpe, S., Alvarez, D.E., Filomatori, C.V.
A conserved Y-shaped RNA structure in the 3’UTR of chikungunya virus genome as a host-specialized element that modulates viral replication and evolution(2023) PLoS pathogens, 19 (5), p. e1011352. DOI: 10.1371/journal.ppat.1011352
Valsecchi, W.M., Faraj, S.E., Cerf, N.T., Fedosova, N.U., Montes, M.R.
The transported cations impose differences in the thermostability of the gastric H,K-ATPase. A kinetic analysis(2022) Biochimica et Biophysica Acta – Biomembranes, 1864 (11), art. no. 184006. DOI: 10.1016/j.bbamem.2022.184006
Faraj, S.E., Valsecchi, W.M., Cerf, N.T., Fedosova, N.U., Rossi, R.C., Montes, M.R. The interaction of Na+, K+, and phosphate with the gastric H,K-ATPase. Kinetics of E1–E2 conformational changes assessed by eosin fluorescence measurements (2021) Biochimica et Biophysica Acta – Biomembranes, 1863 (1), art. no. 183477. DOI: 10.1016/j.bbamem.2020.183477
Faraj, S.E., Rossi, R.C., Montes, M.R. How to distinguish ligand-binding mechanisms: an example of conformational selection disguised as an induced fit (2021) Journal of Biological Education, 55 (3), pp. 238-253. DOI: 10.1080/00219266.2019.1679657
Filomatori, C.V., Bardossy, E.S., Merwaiss, F., Suzuki, Y., Henrion, A., Saleh, M.C., Alvarez, D.E. RNA recombination at Chikungunya virus 3’UTR as an evolutionary mechanism that provides adaptability (2019) PLoS Pathogens, 15 (4), art. no. e1007706. DOI: 10.1371/journal.ppat.1007706
Faraj, S.E., Centeno, M., Rossi, R.C., Montes, M.R. A kinetic comparison between E2P and the E2P-like state induced by a beryllium fluoride complex in the Na,K-ATPase. Interactions with Rb+ (2019) Biochimica et Biophysica Acta – Biomembranes, 1861 (2), pp. 355-365. DOI: 10.1016/j.bbamem.2018.10.020
Monti, J.L.E., Montes, M.R., Rossi, R.C. Steady-state analysis of enzymes with non-Michaelis-Menten kinetics: The transport mechanism of Na-/K—ATPase (2018) Journal of Biological Chemistry, 293 (4), pp. 1373-1385. DOI: 10.1074/jbc.M117.799536
Filomatori, C.V., Lodeiro, M.F., Alvarez, D.E., Samsa, M.M., Pietrasanta, L., Gamarnik, A.V. A 5′ RNA element promotes dengue virus RNA synthesis on a circular genoma (2006) Genes and Development, 20 (16), pp. 2238-2249. DOI: 10.1101/gad.1444206
Montes, M.R., González-Lebrero, R.M., Garrahan, P.J., Rossi, R.C.
Quantitative Analysis of the Interaction between the Fluorescent Probe Eosin and the Na+/K+-ATPase Studied through Rb + Occlusion (2004) Biochemistry, 43 (7), pp. 2062-2069. DOI: 10.1021/bi0351763
Enlace al sitio del laboratorio
Environmental hyperosmolality regulates phospholipid biosynthesis in the renal epithelial cell line MDCK. Casali C, Weber, K, Favale, N, Fernández-Tome MC, (2013) Journal of Lipid Research. ;54(3):677-91. (doi: 10.1194/jlr)
Coordinate regulation between the nuclear receptor peroxisome proliferator-activated receptor-γ and cyclooxygenase-2 in renal epithelial cells. Casali C, Weber, K, Faggionatto, D, Morel Gómez E,Fernández-Tome MC, (2014). Biochemical Pharmacology Aug 15; 90(4):432-9. (doi: 10.1016/j.bcp.2014.06.002)
TAG synthesis and storage under osmotic stress. A requirement for preserving membrane homeostasis in renal cells. Karen Weber; Cecilia I Casali.; Virginia Gaveglio.; Susana Pasquare.; Emanuel Morel Gomez; Leandro Parra,t; Cecilia Perazzo; Maria Fernandez Tome. BBA – Molecular and Cell Biology of Lipids (2018), 1863 (9): 1108-1120.
Sequential and synchronized hypertonicity-induced activation of Rel-family transcription factors is required for osmoprotection in MDCK cells. Cecilia Casali, Luciana Erjavec, María Fernandez Tome. Heliyon (2018) Volume 4, Issue 12, e01072; doi.org/ 10.1016/ j.heliyon.2018.e01072
X-box binding protein 1 (XBP1): a key protein for renal osmotic adaptation. Its role in lipogenic program regulation. Cecilia Casali, Ricardo Malvicini, Leandro Parra, Luciana Erjavec, Ayelen Artuch, Maria del Carmen Fernandez-Tome. (2020) Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids Available online 09 January 2020, DOI 10.1016/j.bbalip.2020.158616. Volume 1865, Issue 4, April 2020, 158616: 1-13.
Bioavailable wine pomace attenuates oxalate-induced type II epithelial mesenchymal transition and preserve the differentiated phenotype of renal MDCK cells Gisela Gerardi; Cecilia Casali; Mónica Cavia-Saiz; María Dolores Rivero-Pérez; Cecilia Perazzo; María Luisa González-SanJosé; Pilar Muñiz, María del Carmen Fernández-Tome. Heliyon (2020) Volume 6, Issue 11, November 2020, e05396. doi.org/ 10.1016/j.heliyon.2020. e05396.
Analysis of XBP1 contribution to hyperosmolarity-induced lipid synthesis. Cecilia I Casali, Leandro Parra, Luciana Erjavec, María del Carmen Fernández-Tome Springer-Nature. (2022). in The Unfolded Protein Response, Methods in Molecular Biology, Springer-Nature. (2022). 10.1007/978-1-0716-1732-8
Dynamics of differentiated-renal epithelial cell monolayer after calcium oxalate injury: the role of cyclooxygenase-2. Cecilia I. Casali, Lucila G. Pescio, Dylan E. Sendyk, Emanuel Morel Gómez, Luciana C. Erjavec, Leandro G. Parra, María C. Fernández-Tomé. (2023) Enviado a Life Sciences. Life Sciences 319 (2023) 121544
Dynamic recycling of extracellular ATP in human epithelial intestinal cells. 2023. PLOS Computational Biology (en prensa).
Interactive dynamics of cell volume and cell death in human erythrocytes exposed to α-hemolysin from Escherichia coli. International Journal of Molecular Sciences. 20222 23 (2) p 872. doi: 10.3390/ijms23020872
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Enlace al sitio del laboratorio
Gallego SM; Benavides MP and Tomaro ML. Effect of heavy metal ion excess on sunflower leaves: Evidence for involvement of oxidative stress. Plant Science 35: 87-94 (1996). ISSN: 0168-9452
Groppa MD, Tomaro ML and Benavides MP. Polyamines as Protectors Against Cadmium or Copper-Induced Oxidative Damage in Sunflower Leaf Discs. Plant Sci. 161/3, 481-488 (2001). ISSN 0168-9452
Laspina NV, Groppa MD, Tomaro ML and Benavides MP. Nitric oxide protects sunflower leaves against cadmium induced oxidative stress. Plant Science 167: 323-330 (2005). ISSN 0168-9452
Groppa MD, Ianuzzo MP, Tomaro ML and Benavides MP. Polyamine metabolism in sunflower plants under long-term cadmium or copper stress. Amino Acids 32(2): 265-275 (2007) ISSN0939-4451
Groppa MD, Rosales EP, Iannone MF., Benavides MP. Nitric oxide, polyamines and Cd-induced phytotoxicity in wheat roots. Phytochemistry 69: 2609-2615 (2008). ISSN 0031-9422
Rosales EP, Iannone MF, Groppa MD, Benavides MP. Nitric oxide inhibits nitrate reductase activity in wheat leaves. Plant Physiol. Biochem.124-130 (2011). https://doi.org/10.1016/j.plaphy.2010.10.009. ISSN 0981-9428 IF 2.838
Gallego SM, Pena LB, Barcia RA, Azpilicueta CE, Iannone MF, Rosales EP, Zawoznik MS, Groppa MD, Benavides MP. Unravelling cadmium toxicity and tolerance in plants: Insight into regulatory mechanisms. Environmental Experimental Botany 83 33– 46. (2012) ISSN: 0098-8472. IF 2.578
Rosales EP, Iannone MF, Groppa MD, Benavides MP. Polyamines modulate nitrate reductase activity in wheat leaves: involvement of nitric oxide. Amino Acids 42 (2-3)857-865(2012) ISSN 0939-445
Iannone MF, Groppa MD, Patricia Benavides MP. Cadmium induces different biochemical responses in wild type and catalase-deficient tobacco plants. Environ Exp Botany. 109: 201–211 (2015) ISSN: 0098-8472. IF 3.712
Benavides MP, Groppa MD, Recalde L, Verstraeten SV. Effects of polyamines on cadmium- and copper-mediated alterations in wheat (Triticum aestivum L) and sunflower (Helianthus annuus L) seedling membrane fluidity. Archives of Biochemistry and Biophysics 654: 27-39 (2018). doi.org/10.1016/j.abb.2018.07.008. ISSN 0003-9861
Vazquez A, Recalde L, Cabrera A, Groppa MD, Benavides MP. Does nitrogen source influence cadmium distribution in Arabidopsis plants? Ecotoxicology and Environmental Safety 191 (2020), pp 1-9. https://doi.org/10.1016/j.ecoenv.2020.110163
Recalde L., Gómez Mansur NM, Cabrera AV, Matayoshi CL, Gallego SM, Groppa MD, Benavides MP. Unravelling ties in the nitrogen network: polyamines and nitric oxide emerging as essential players in the signaling roadway. Ann Appl Biology (2021) 178 (2), 192–208. https://doi.org/10.1111/aab.12642.
Enlace al sitio del laboratorio
Pasquini LA, Paez P, Besio Moreno M, Pasquini J M y Soto EF. Inhibition of the proteasome by lactacystin enhances oligodendroglial cell differentiation The Journal of Neuroscience, Society for Neuroscience, EEUU. June 1, 23(11) 4635-4644 (2003). IF2003 8,22
Pasquini, L.A., Calatayud, C.A., Bertone Uña, A.L., Millet, V., Pasquini, J.M. and Soto, E. F. The Neurotoxic Effect of Cuprizone on Oligodendrocytes Depends on the Presence of Pro-inflammatory Cytokines secreted by Microglia. Neurochemical Research. Springer Science, EEUU. Feb;32(2):279-92 (2007). IF 2,472
Pasquini L.A., Millet V, Hoyos H.C, Giannoni J.P., Croci, DO, Liu F.T., Marder, M, Rabinovich G.A. and Pasquini J.M. Galectin-3 drives oligodendrocyte differentiation to control myelin integrity and function. Cell Death Differ. NATURE PUBLISHING GROUP, UK. 2011 Nov;18(11):1746-56. doi: 10.1038/cdd.2011.40. IF2011 8,849
Héctor R. Quintá, Juana M. Pasquini, Gabriel A. Rabinovich and Laura A. Pasquini. Glycan-dependent binding of Galectin-1 to Neuropilin-1 promotes functional recovery of spinal cord injury through interruption of the Semaphorin 3A pathway. Cell Death Differ. NATURE PUBLISHING GROUP, UK. 2014 Jun;21(6):941-55. IF2014 8.184
Hoyos, H.C, Marder, M, Rabinovich G.A, Pasquini, J.M and Pasquini, L.A. Galectin-3 controls the response of microglial cells to limit cuprizone-induced demyelination. Neurobiology of Disease. ELSEVIER SCIENCE, EEUU. 2014 Feb; 62:441-55 IF2014 5,82
Rinaldi M, Thomas L, Mathieu P, Carabias P, Troncoso MF, Pasquini JM, Rabinovich GA, Pasquini LA. Galectin-1 circumvents lysolecithin-induced demyelination through the modulation of microglial polarization/phagocytosis and oligodendroglial differentiation. Neurobiology of disease. ELSEVIER SCIENCE, EEUU. 2016 Dec;96:127-143. IF2016 5,12
Thomas L., Pasquini L.A. «Extracellular Galectin-3 induces accelerated oligodendroglial differentiation through changes in signaling pathways and cytoskeleton dynamics». Mol Neurobiol. Springer. 2019 Jan;56(1):336-349. doi: 10.1007/s12035-018-1089-6. Epub 2018 Apr 27. IF 5.076
Wies Mancini V.S.B., Pasquini J.M., Correale J.D., Pasquini L.A. Microglial modulation through CSF-1R inhibition attenuates demyelination and promotes remyelination. Glia. Wiley, EEUU. 2019 Feb;67(2):291-308. doi: 10.1002/glia.23540. Epub 2018 Nov 19. IF 6.2
Thomas L, Pasquini LA. Galectin-3 exerts a pro-differentiating and pro-myelinating effect within a temporal window spanning precursors and pre-oligodendrocytes: insights into the mechanisms of action. Mol Neurobiol. 2020 Feb;57(2):976-987. doi: 10.1007/s12035-019-01787-3. Epub 2019 Oct 25. PMID: 31654317. IF 5.076
Wies Mancini VSB, Di Pietro AA, de Olmos S, Silva Pinto P, Vence M, Marder M, Igaz LM, Marcora MS, Pasquini JM, Correale JD, Pasquini LA. Colony-stimulating factor-1 receptor inhibition attenuates microgliosis and myelin loss but exacerbates neurodegeneration in the chronic cuprizone model. J Neurochem. 2021 Dec 22. doi: 10.1111/jnc.15566. Epub ahead of print. PMID: 34935149. IF 5.372.
Marziali LN, Correale J, Garcia CI, Pasquini JM. “Combined effects of transferrin and thyroid hormone during oligodendrogenesisIn vitro”.Glia. 2016 Nov;64(11):1879-91. doi: 10.1002/glia.23029. Epub 2016 Jul 22.
Farrelly L, Rosato-Siri MV, Föcking M, Codagnone M, Reines A, Dicker P, Wynne K, Farrell M, Cannon M, Cagney G, Pasquini JM, Cotter DR. “The effect of prenatal deficiency of risperidone treatment on the rat frontal cortex. A proteomic analysis”. Proteomics. 2017 Sep;17(17-18). doi: 10.1002/pmic.201600407.
Rosato-Siri MV, Marziali L, Guitart ME, Badaracco ME, Puntel M, Pitossi F, Correale J, Pasquini JM.” Iron Availability Compromises Not Only Oligodendrocytes But Also Astrocytes and Microglial Cells”. MolNeurobiol.2017 Jan 14.doi: 10.1007/s12035-016-0369-2. [Epub ahead of print]
Cheli VT, Santiago González DA, Marziali LN, Zamora NN, Guitart ME, Spreuer V, Pasquini JM, Paez PM “The Divalent Metal Transporter 1 (DMT1) Is Required for Iron Uptake and Normal Development of Oligodendrocyte Progenitor Cells”. J Neurosci. 2018; 38(43):9142-9159. doi: 10.1523/JNEUROSCI.1447-18.2018.
Carden TR, Correale J, Pasquini JM, Pérez MJ “Transferrin Enhances Microglial Phagocytic Capacity”..MolNeurobiol.2019 Feb 13.doi: 10.1007/s12035-019-1519-0. [Epub ahead of print]
125 Guitart ME, Vence M, Correale J, Pasquini JM, Rosato-Siri MV “Ontogenetic oligodendrocyte maturation through gestational iron deprivation: The road not taken”. Glia. 2019 67:1760-1774.
Mattera VS, Pereyra Gerber P, Glisoni R, Ostrowski M, Verstraeten SV, Pasquini JM, Correale JD “ Extracellular vesicles containing the transferrin receptor as nanocarriers of apotransferrin”.J Neurochem. 2020 155(3):327-338.
Rosato-Siri MV, Marziali LN, Mattera V, Correale J, Pasquini JM “Combination therapy of apo-transferrin and thyroid hormones enhances remyelination”. Glia. 2021 Jan;69(1):151-164. doi: 10.1002/glia.23891. Epub 2020 Aug 20.
Pérez MJ, Carden TR, Dos Santos Claro PA, Silberstein S, Páez PM, Cheli VT, Correale J, Pasquini JM. “Transferrin Enhances Neuronal Differentiation”. ASN Neuro. 2023 Jan-Dec;15:17590914231170703. doi: 10.1177/17590914231170703.PMID: 37093743
Rosato-Siri MV, Adami PVM, Guitart ME, Verstraeten S, Morelli L, Correale J, Pasquini JM.Glial Cell Metabolic Profile Upon Iron Deficiency: Oligodendroglial and Astroglial Casualties of BioenergeticAdjustments. MolNeurobiol. 2023 Apr;60(4):1949-1963.
1- Ana L. Rinaldi, Romina Carballo, Impedimetric non-enzymatic glucose sensor based on nickel hydroxide thin film onto gold electrode, Sensors and Actuators B: Chemical, Volume 228, 2016,
Pages 43-52, ISSN 0925-4005,
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2-Ana L. Rinaldi, Enrique Rodríguez-Castellón, Santiago Sobral, Romina Carballo, Application of a nickel hydroxide gold nanoparticles screen-printed electrode for impedimetric sensing of glucose in artificial saliva, Journal of Electroanalytical Chemistry, Volume 832, 2019, Pages 209-216, ISSN 1572-6657,
https://doi.org/10.1016/j.jelechem.2018.11.008.
3-Silvia Soto Espinoza, Berenice Cros, Sofía Ávila, Gabriela Lezcano, Paula Dabas, Nora Vizioli, Romina Carballo, Preparation of a biomimetic Cu(II) protoporphyrin magnetic nanocomposite and its application for the selective adsorption of angiotensin I, Microchemical Journal, Volume 170, 2021, 106691, ISSN 0026-265X,
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4-Scodeller, P., Carballo, R., Szamocki, R., Levin, L., Forchiassin, F., Calvo, E.J. Layer-by-layer self-assembled osmium polymer-mediated laccase oxygen cathodes for biofuel cells: The role of hydrogen peroxide, J. Am. Chem. Soc. 2010, 132, 32, 11132–11140
https://doi.org/10.1021/ja1020487
C Gordon Falconi, MF Iannone, MS Zawoznik, LH Cumbal Flores, AP Martial Debut, MD Groppa (2020). Synthesis of silver nanoparticles with remediative potential using discarded yerba mate: an eco-friendly approach. Journal of Environmental Chemical Engineering, 8(11): 104425. https://doi.org/10.1016/j.jece.2020.104425
MD Groppa, MS Zawoznik, MP Benavides, MF Iannone (2022). Beneficial effects of magnetite nanoparticles on soybean-Bradyrhizobium japonicum and alfalfa-Sinorhizobium meliloti associations. Plant Physiology and Biochemistry, 180: 42-49. https://doi.org/10.1016/j.plaphy.2022.03.025.
MF Iannone, MD Groppa, MS Zawoznik, DF Coral, MB Fernández van Raap, MP Benavides (2021). Magnetite nanoparticles coated with citric acid are not phytotoxic and stimulate soybean and alfalfa growth. Ecotoxicology and Environmental Safety, 211: 111942. https://doi.org/10.1016/j.ecoenv.2021.111942
MF Iannone, MD Groppa, ME de Sousa, MB Fernández van Raap, MP Benavides (2016) Impact of Magnetite Iron Oxide nanoparticles on wheat (Triticum aestivum L.) development: Evaluation of oxidative damage. Journal of Environmental and Experimental Botany, 131: 77–88. https://doi.org/10.1016/j.envexpbot.2016.07.004
Marcucci, C., Rademacher, M., Kamecki, F., Pastore, V., Bach, H.G., Ricco, R.A., Wagner, M.L., Knez, D., Gobec, S., Colettis, N., Marder, M. Biological Evaluation of Valeriana Extracts from Argentina with Potent Cholinesterase Inhibition for the Treatment of Neurodegenerative Disorders and Their Comorbidities—The Case of Valeriana carnosa Sm. (Caprifoliaceae) Studied in Mice (2023) Pharmaceuticals, 16 (1), art. no. 129. DOI: 10.3390/ph16010129
Kamecki, F., Knez, D., Carvalho, D., Marcucci, C., Rademacher, M., Higgs, J., Žakelj, S., Marcos, A., de Tezanos Pinto, F., Abin-Carriquiry, J.A., Gobec, S., Colettis, N., Marder, M. Multitarget 2′-hydroxychalcones as potential drugs for the treatment of neurodegenerative disorders and their comorbidities (2021) Neuropharmacology, 201, art. no. 108837. DOI: 10.1016/j.neuropharm.2021.108837
Marcucci, C., Relats, J.M.A., Bach, H.G., Kamecki, F., Varela, B.G., Wagner, M.L., Pastore, V., Colettis, N., Ricco, R.A., Marder, M. Neurobehavioral evaluation and phytochemical characterization of a series of argentine valerian species (2020) Heliyon, 6 (12), art. no. e05691. DOI: 10.1016/j.heliyon.2020.e05691
Higgs, J., Wasowski, C., Marcos, A., Jukič, M., Paván, C.H., Gobec, S., de Tezanos Pinto, F., Colettis, N., Marder, M. Chalcone derivatives: synthesis, in vitro and in vivo evaluation of their anti-anxiety, anti-depression and analgesic effects (2019) Heliyon, 5 (3), art. no. e01376. DOI: 10.1016/j.heliyon.2019.e01376
Pastore, V., Wasowski, C., Martin, P., Enrique, A., Higgs, J., Bruno-Blanch, L.E., Milesi, V., Marder, M. N-propyl-2,2-diphenyl-2-hydroxyacetamide, a novel α-hydroxyamide with anticonvulsant, anxiolytic and antidepressant-like effects that inhibits voltage-gated sodium channels (2018) European Journal of Pharmacology, 819, pp. 270-280. DOI: 10.1016/j.ejphar.2017.11.048
Pastore, V., Wasowski, C., Higgs, J., Mangialavori, I.C., Bruno-Blanch, L.E., Marder, M. A synthetic bioisoster of trimethadione and phenytoin elicits anticonvulsant effect, protects the brain oxidative damage produced by seizures and exerts antidepressant action in mice (2014) European Neuropsychopharmacology, 24 (8), pp. 1405-1414. DOI: 10.1016/j.euroneuro.2014.04.005
Higgs, J., Wasowski, C., Loscalzo, L.M., Marder, M. In vitro binding affinities of a series of flavonoids for m-opioid receptors. Antinociceptive effect of the synthetic flavonoid 3,3-dibromoflavanone in mice. (2013) Neuropharmacology, 72, pp. 9-19. DOI: 10.1016/j.neuropharm.2013.04.020
Lysosomal permeabilization and endoplamic reticulum stress mediate the apoptotic response induced after photoactivation of a lipophilic Zinc(II) phthalocyanine. Chiarante N, García Vior MC, Rey O, Marino J, Roguin LP. Int J Biochem Cell Biol 103: 89-98, 2018. DOI:10.1016/j.biocel.2018.08.009
Oxidative stress generated by irradiation of a Zinc(II) phthalocyanine induces a dual apoptotic and necrotic response in melanoma cells. Valli F, García Vior MC, Roguin LP, Marino J. Apoptosis 24:119-134, 2019. DOI: 10.1007/s10495-018-01512-w
Zn (II) phthalocyanines as photosensitizers for antitumor photodynamic therapy. Roguin LP, Chiarante N, García Vior MC, Marino J. Int J Biochem Cell Biol 114:105575, 2019. DOI: 10.1016/j.biocel.2019.105575.
A penicillin derivative exerts an anti-metastatic activity in melanoma cells through the downregulation of integrin vβ3 and Wnt/ β-catenin pathway. Barrionuevo E, Cayrol F, Cremaschi GA, Cornier PG, Boggián DB, Delpiccolo CML, Mata EG, Roguin LP, Blank VC. Front. Pharmacol 11:127, 2020. DOI: 10.3389/fphar.2020.00127.
Crosstalk between oxidative stress-induced apoptotic and autophagic signaling pathways in Zn(II) phthalocyanine photodynamic therapy of melanoma. Valli F, Garcia Vior C, Roguin LP, Marino VJ. Free Radic Biol Med 152:743-754, 2020. DOI: 10.1016/j.freeradbiomed.2020.01.018.
In vivo photodynamic therapy with a lipophilic Zinc (II) phthalocyanine inhibits colorectal cancer and induces a Th1/CD8 antitumor immune response. Chiarante N, Duhalde Vega M, Valli F, Zotta E, Daghero H, Basika T, Bollati-Fogolin M, García Vior C, Marino J, Roguin LP. Lasers Surg Med 53:344-358, 2021. DOI: 10.1002/lsm.23284
Contribution of endoplasmic reticulum stress, MAPK and PI3K/Akt pathways to the apoptotic death induced by a penicillin derivative in melanoma cells. Bellizzi Y, Anselmi Relats JM, Cornier PG, Delpiccolo CML, Mata EG, Cayrol F, Cremaschi GA, Blank VC, Roguin LP. Apoptosis 27:34-48, 2022. DOI: 10.1007/s10495-021-01697-7.
Synergistic antitumor effect of a penicillin derivative combined with thapsigargin in melanoma cells. Bellizzi Y, Cornier PG, Delpiccolo CML, Mata EG, Blank VC, Roguin LP. J. Cancer Res. Clin. Oncol 148:3361-3373, 2022. DOI: 10.1007/s00432-022-04129-4
Melanosomal targeting via caveolin-1 dependent endocytosis mediates Zn(II) phthalocyanine phototoxic action in melanoma cells. Valli F, Garcia Vior C, Ezquerra Riega S, Roguin LP, Marino VJ. J Phtochem and Photobiol, B: Biology 234:112505, 2022. DOI: 10.1016/j.jphotobiol.2022.112505.
Antiangiogenic activity of the penicillin derivative TAP7f in melanoma. Barrionuevo E, Cornier PG, Delpiccolo CML, Mata EG, Roguin LP, Blank VC. J Mol Med 101: 249-263, 2023. DOI: 10.1007/s00109-023-02287-7
1- The role of zinc in the modulation of neuronal proliferation and apoptosis.
Ana M. Adamo; María P. Zago; Gerardo G. Mackenzie; Lucila Aimo,; Carl L. Keen; Alison Keenan and Patricia I. Oteiza.
Neurotoxicity Research. (2010) 17(1):1-14. (ISSN: 1029-8428)
DOI: 10.1007/s12640-009-9067-4
2- The Notch Signaling Pathway: Its Role in Focal CNS Demyelination and Apotransferrin- Induced Remyelination.
Evangelina Aparicio, Patricia Mathieu, Milagros Pereira Luppi, Florencia Almeira Gubiani and Ana. M. Adamo.
J. Neurochem. (2013) 127:819–836. (ISSN: 0022-3042)
DOI: 10.1111/jnc.12440
3- GAP-43 slows down cell cycle progression via sequences in its 3’UTR.
Karina De Moliner, Manuel Wolfson, Nora Perrone-Bizzozero and Ana M. Adamo
Archives of Biochemistry and Biophysics (2015) 571:66–75 (ISSN: 0003-9861)
DOI: 10.1016/j.abb.2015.02.024
4- Zinc deficiency affects the STAT1/3 signaling pathways in part through redox-mediated mechanisms.
S. Supasai, L. Aimo, A.M. Adamo, G.G. Mackenzie and P.I. Oteiza
Redox Biology (2017) 11:469–481 (ISSN: 2213-2317).
DOI:10.1016/j.redox.2016.12.027
5- Laura I. Gómez Pinto, Débora Rodríguez, Ana M. Adamo and Patricia A. Mathieu. TGF-β pro-oligodendrogenic effects on adult SVZ progenitor cultures and its interaction with the Notch signaling pathway. Glia.(2018) 66 (2), 396-412, 2018. DOI:10.1002/glia.23253
6- Patricia A. Mathieu, María F. Almeira Gubiani, Débora Rodriguez, Laura I. Gómez Pinto, María de Luján Calcagno and Ana M. Adamo. Demyelination-remyelination in the Central Nervous System: ligand-dependent participation of the Notch signaling pathway. Toxicological Sciences, (2019) 171(1), 172–192.
DOI: 10.1093/toxsci/kfz130
7- Adamo, A.M.*, Liu, X.Z. *, Mathieu, P., Nuttall, J.R., Supasai S., and Oteiza, P.I. (*contribución igualitaria). Early developmental marginal zinc deficiency affects neurogenesis decreasing neuronal number and altering neuronal specification in the adult rat brain. Frontiers in Cellular Neuroscience (2019), 13:62, 2019.
DOI: 10.3389/fncel.2019.00062
8- Suangsuda Supasai, Ana M. Adamo, Patricia Mathieu, Regina C. Marino, Adelaide C. Hellmers, Eleonora Cremonini, Patricia I. Oteiza. Gestational zinc deficiency impairs brain astrogliogenesis in rats through multistep alterations of the JAK/STAT3 signaling pathway. Redox Biology (2021) 44-102017. https://doi.org/10.1016/j.redox.2021.102017
9- Di-2-ethylhexyl phthalate affects zinc metabolism and neurogenesis in the developing rat brain
Liu, Xiuzhen; Adamo, Ana; Oteiza, Patricia I.
Archives of Biochemistry and Biophysics (2022) 727:109351.
DOI: 10.1016/j.abb.2022.109351
10- Patricia A. Mathieu, Yim Rodriguez Sampertegui, Fernanda Elias, Alexis Silva Silva, María de Luján Calcagno, Ricardo López and Ana M. Adamo. Oligodeoxynucleotide IMT504: Effects on central nervous system repair following demyelination (en revisión).
Gowtham T, Rajan P, Kanaga V, Sucharita B, Lavanyaa M, Deepthi J, Paz A, Grandfield S, Nayak V, Bredeston LM, Abramson J, Subramanian R (2023) Biochemical characterization of a GDP-mannose transporter from Chaetomium thermophilum. PLOS ONE doi.org/10.1371/journal.pone.0280975
Schwarzbaum PJ, Schachter J, Bredeston LM (2022) The broad range di- and trinucleotide exchanger SLC35B1 displays asymmetrical affinities for ATP transport across the ER membrane. Journal of Biological Chemistry 298, 101537 doi.org/10.1016/j.jbc.2021.101537
Argentinian AntiCovid Consortium-All authors, listed in alphabetical order, contributed equally to this work (2022) Covalent coupling of Spike’s receptor binding domain to a multimeric carrier produces a high immune response against SARS-CoV-2. Scientific Reports. 12, 692 doi.org/10.1038/s41598-021-03675-0
Argentinian AntiCovid Consortium-All authors, listed in alphabetical order, contributed equally to this work (2020) Structural and functional comparison of SARS-CoV-2-spike receptor binding domain produced in Pichia pastoris and mammalian cells. Scientific Reports 10, 21779 doi.org/10.1038/s41598-020-78711-6
Toscanini A, Favarolo MB, Gonzalez-Flecha FL, Evert B, Rautengarten C, Bredeston LM (2019) The conserved Glu47 and Lys50 residues are critical for UDP-N-acetylglucosamine/UMP antiport activity of the Golgi SLC35A3 transporter. The Journal of Biological Chemistry 294, 10042-10054 doi.org/10.1074/jbc.RA119.008827
Bredeston LM, Marino Buslje C, Mattera V, Buzzi L, Parodi AJ, D’Alessio C (2017) The conundrum of UDP-Glc Entrance into the yeast ER lumen. Glycobiology 27, 64-79 doi.org/10.1093/glycob/cww092
Bredeston LM, González-Flecha L (2016) The promiscuous phosphomonoestearase activity of Archaeoglobus fulgidus CopA, a thermophilic Cu+ transport ATPase. Biochim Biophys Acta. 1858, 1471-8 doi.org/10.1016/j.bbamem.2016.04.006
Bredeston LM, Caffaro CE, Samuelson J, Hirschberg CB (2005) Golgi and endoplasmic reticulum functions take place in different subcellular compartments of Entamoeba histolytica. The Journal of Biological Chemistry 280, 32168-32176 doi.org/10.1074/jbc.M507035200
Bredeston LM, Adamo HP (2004) Loss of autoinhibition of the plasma membrane Ca2+ pump by substitution of aspartic 170 by asparagine. Activation of PMCA4 without disruption of the interaction between the catalytic core and the C-terminal regulatory domain. The Journal of Biological Chemistry 279, 41619-625 doi.org/10.1074/jbc.M403116200